Prof. Gerald Misinzo

Gerald Misinzo BVM MSc PhD is an Associate Professor of Virology and Head of the Department of Microbiology, Parasitology and Immunology, College of Veterinary and Medical Sciences, Sokoine University of Agriculture (SUA), Tanzania. He is Centre Leader of SACIDS – African Center of Excellence for Infectious Diseases of Humans and Animals in Southern and East Africa (SACIDS-ACE), a One Health partnership of medical and veterinary institutions.
 
The core partnership of the Center is SUA, Muhimbili University of Health and Allied Sciences (MUHAS) and the Tanzania National Institute for Medical Research (NIMR). The Vision and Mission of the Center are rooted in the quest for enhancing Africa’s capacity for the science evidence based risk management of infectious diseases through the One Health approach. SACIDS focus is to address infectious diseases in the African endemic settings through a collaborative effort between natural and social sciences to advance the understanding of interactions between humans, animals and the environment to improve public and animal health.
 
The Centre proactively pursues the goal of developing effective African research capacity for infectious diseases through postgraduate training and research programs that focus on African problems through the lens of African health and economic development and in context of the global agenda.

http://www.sacids.org

 

Publications

Co-circulation of multiple genotypes of African swine fever viruses among domestic pigs in Zambia (2013-2015).

Simulundu E, Chambaro HM, Sinkala Y, Kajihara M, Ogawa H, Mori A, Ndebe J, Dautu G, Mataa L, Lubaba CH, Simuntala C, Fandamu P, Simuunza M, Pandey GS, Samui KL, Misinzo G, Takada A, Mweene AS.

Transbound Emerg Dis. 2017 Mar 15. doi: 10.1111/tbed.12635. [Epub ahead of print]

 

Mosquito-borne viruses circulating in Kinshasa, Democratic Republic of the Congo.

Mbanzulu KM, Wumba R, Mukendi JK, Zanga JK, Shija F, Bobanga TL, Aloni MN, Misinzo G.

Int J Infect Dis. 2017 Apr;57:32-37. doi: 10.1016/j.ijid.2017.01.016. Epub 2017 Jan 30.

 

Current Epidemiological Assessment of Bancroftian Filariasis in Tanga Region, Northeastern Tanzania.

Mshana HJ, Baraka V, Misinzo G, Makunde WH.

J Trop Med. 2016;2016:7408187. doi: 10.1155/2016/7408187. Epub 2016 Dec 6.

 

History and current status of peste des petits ruminants virus in Tanzania.

Torsson E, Kgotlele T, Berg M, Mtui-Malamsha N, Swai ES, Wensman JJ, Misinzo G.

Infect Ecol Epidemiol. 2016 Oct 20;6:32701. doi: 10.3402/iee.v6.32701. eCollection 2016. Review.

 

Climate Change Influences Potential Distribution of Infected Aedes aegypti Co-Occurrence with Dengue Epidemics Risk Areas in Tanzania.

Mweya CN, Kimera SI, Stanley G, Misinzo G, Mboera LE.

PLoS One. 2016 Sep 28;11(9):e0162649. doi: 10.1371/journal.pone.0162649. eCollection 2016.

 

Historical environmental change in Africa drives divergence and admixture of Aedes aegypti mosquitoes: a precursor to successful worldwide colonization?

Bennett KL, Shija F, Linton YM, Misinzo G, Kaddumukasa M, Djouaka R, Anyaele O, Harris A, Irish S, Hlaing T, Prakash A, Lutwama J, Walton C.

Mol Ecol. 2016 Sep;25(17):4337-54. doi: 10.1111/mec.13762. Epub 2016 Aug 10.

 

Human leptospirosis in Tanzania: sequencing and phylogenetic analysis confirm that pathogenic Leptospira species circulate among agro-pastoralists living in Katavi-Rukwa ecosystem.

Muller SK, Assenga JA, Matemba LE, Misinzo G, Kazwala RR.

BMC Infect Dis. 2016 Jun 10;16:273. doi: 10.1186/s12879-016-1588-x.

 

Diagnosis and genotyping of African swine fever viruses from 2015 outbreaks in Zambia.

Thoromo J, Simulundu E, Chambaro HM, Mataa L, Lubaba CH, Pandey GS, Takada A, Misinzo G, Mweene AS.

Onderstepoort J Vet Res. 2016 Apr 29;83(1):a1095. doi: 10.4102/ojvr.v83i1.1095.

 

Morphological and molecular detection of canine dirofilarial species of veterinary and medical importance in Morogoro municipality, Tanzania.

Mukendi JP, Kimbita E, Mbanzulu KM, Maindo PP, Misinzo G.

Vet Parasitol. 2016 Apr 15;220:1-3. doi: 10.1016/j.vetpar.2016.02.005. Epub 2016 Feb 6.

 

The Risk of Dengue Virus Transmission in Dar es Salaam, Tanzania during an Epidemic Period of 2014.

Mboera LE, Mweya CN, Rumisha SF, Tungu PK, Stanley G, Makange MR, Misinzo G, De Nardo P, Vairo F, Oriyo NM.

PLoS Negl Trop Dis. 2016 Jan 26;10(1):e0004313. doi: 10.1371/journal.pntd.0004313. eCollection 2016 Jan.

 

Molecular Differentiation of the African Yellow Fever Vector Aedes bromeliae (Diptera: Culicidae) from Its Sympatric Non-vector Sister Species, Aedes lilii.

Bennett KL, Linton YM, Shija F, Kaddumukasa M, Djouaka R, Misinzo G, Lutwama J, Huang YM, Mitchell LB, Richards M, Tossou E, Walton C.

PLoS Negl Trop Dis. 2015 Dec 7;9(12):e0004250. doi: 10.1371/journal.pntd.0004250. eCollection 2015 Dec.

 

A study of Rift Valley fever virus in Morogoro and Arusha regions of Tanzania - serology and farmers' perceptions.

Wensman JJ, Lindahl J, Wachtmeister N, Torsson E, Gwakisa P, Kasanga C, Misinzo G.

Infect Ecol Epidemiol. 2015 Nov 18;5:30025. doi: 10.3402/iee.v5.30025. eCollection 2015.

 

Batrachochytrium dendrobatidis detected in Kihansi spray toads at a captive breeding facility (Kihansi, Tanzania).

Makange M, Kulaya N, Biseko E, Kalenga P, Mutagwaba S, Misinzo G.

Dis Aquat Organ. 2014 Sep 30;111(2):159-64. doi: 10.3354/dao02775.

 

Partial genetic characterization of peste des petits ruminants virus from goats in northern and eastern Tanzania.

Kgotlele T, Macha ES, Kasanga CJ, Kusiluka LJ, Karimuribo ED, Van Doorsselaere J, Wensman JJ, Munir M, Misinzo G.

Transbound Emerg Dis. 2014 Aug;61 Suppl 1:56-62. doi: 10.1111/tbed.12229.

 

Preliminary investigation on presence of peste des petits ruminants in Dakawa, Mvomero district, Morogoro region, Tanzania.

Kgotlele T, Kasanga CJ, Kusiluka LJ, Misinzo G.

Onderstepoort J Vet Res. 2014;81(2):E1-3.

 

Molecular characterization of African swine fever virus from domestic pigs in northern Tanzania during an outbreak in 2013.

Misinzo G, Kwavi DE, Sikombe CD, Makange M, Peter E, Muhairwa AP, Madege MJ.

Trop Anim Health Prod. 2014 Oct;46(7):1199-207. doi: 10.1007/s11250-014-0628-z. Epub 2014 Jul 5.

 

Epidemiological investigation into the introduction and factors for spread of Peste des Petits Ruminants, southern Tanzania.

Muse EA, Karimuribo ED, Gitao GC, Misinzo G, Mellau LS, Msoffe PL, Swai ES, Albano MO.

Onderstepoort J Vet Res. 2012 Jun 20;79(2):457. doi: 10.4102/ojvr.v79i2.457.

 

African swine fever virus, Tanzania, 2010-2012.

Misinzo G, Kasanga CJ, Mpelumbe-Ngeleja C, Masambu J, Kitambi A, Van Doorsselaere J.

Emerg Infect Dis. 2012 Dec;18(12):2081-3. doi: 10.3201/eid1812.121083. No abstract available.

 

Development of a One Health National Capacity in Africa : the Southern African Centre for Infectious Disease Surveillance (SACIDS) One Health Virtual Centre Model.

Rweyemamu M, Kambarage D, Karimuribo E, Wambura P, Matee M, Kayembe JM, Mweene A, Neves L, Masumu J, Kasanga C, Hang'ombe B, Kayunze K, Misinzo G, Simuunza M, Paweska JT.

Curr Top Microbiol Immunol. 2013;366:73-91. doi: 10.1007/82_2012_244. Review.

 

Cell tropism and entry of porcine circovirus 2.

Nauwynck HJ, Sanchez R, Meerts P, Lefebvre DJ, Saha D, Huang L, Misinzo G.

Virus Res. 2012 Mar;164(1-2):43-5. doi: 10.1016/j.virusres.2011.11.003. Epub 2011 Nov 11. Review.

 

Capacity-building efforts by the AFHSC-GEIS program.

Sanchez JL, Johns MC, Burke RL, Vest KG, Fukuda MM, Yoon IK, Lon C, Quintana M, Schnabel DC, Pimentel G, Mansour M, Tobias S, Montgomery JM, Gray GC, Saylors K, Ndip LM, Lewis S, Blair PJ, Sjoberg PA, Kuschner RA, Russell KL, Blazes DL; AFHSC-GEIS Capacity Building Writing Group, Witt CJ, Money NN, Gaydos JC, Pavlin JA, Gibbons RV, Jarman RG, Stoner M, Shrestha SK, Owens AB, Iioshi N, Osuna MA, Martin SK, Gordon SW, Bulimo WD, Waitumbi DJ, Assefa B, Tjaden JA, Earhart KC, Kasper MR, Brice GT, Rogers WO, Kochel T, Laguna-Torres VA, Garcia J, Baker W, Wolfe N, Tamoufe U, Djoko CF, Fair JN, Akoachere JF, Feighner B, Hawksworth A, Myers CA, Courtney WG, Macintosh VA, Gibbons T, Macias EA, Grogl M, O'Neil MT, Lyons AG, Houng HS, Rueda L, Mattero A, Sekonde E, Sang R, Sang W, Palys TJ, Jerke KH, Millard M, Erima B, Mimbe D, Byarugaba D, Wabwire-Mangen F, Shiau D, Wells N, Bacon D, Misinzo G, Kulanga C, Haverkamp G, Kohi YM, Brown ML, Klein TA, Meyers M, Schoepp RJ, Norwood DA, Cooper MJ, Maza JP, Reeves WE, Guan J.

BMC Public Health. 2011 Mar 4;11 Suppl 2:S4. doi: 10.1186/1471-2458-11-S2-S4. Review.

 

Genetic characterization of African swine fever viruses from a 2008 outbreak in Tanzania.

Misinzo G, Magambo J, Masambu J, Yongolo MG, Van Doorsselaere J, Nauwynck HJ.

Transbound Emerg Dis. 2011 Feb;58(1):86-92. doi: 10.1111/j.1865-1682.2010.01177.x. Epub 2010 Oct 22.

 

Porcine reproductive and respiratory syndrome virus entry into the porcine macrophage.

Van Breedam W, Delputte PL, Van Gorp H, Misinzo G, Vanderheijden N, Duan X, Nauwynck HJ.

J Gen Virol. 2010 Jul;91(Pt 7):1659-67. doi: 10.1099/vir.0.020503-0. Epub 2010 Apr 21. Review.

 

Porcine circovirus 2 infection of epithelial cells is clathrin-, caveolae- and dynamin-independent, actin and Rho-GTPase-mediated, and enhanced by cholesterol depletion.

Misinzo G, Delputte PL, Lefebvre DJ, Nauwynck HJ.

Virus Res. 2009 Jan;139(1):1-9. doi: 10.1016/j.virusres.2008.09.005. Epub 2008 Nov 12.

 

Involvement of proteases in porcine reproductive and respiratory syndrome virus uncoating upon internalization in primary macrophages.

Misinzo GM, Delputte PL, Nauwynck HJ.

Vet Res. 2008 Nov-Dec;39(6):55. doi: 10.1051/vetres:2008031. Epub 2008 Jul 25.

 

Increased porcine circovirus type 2 replication in porcine leukocytes in vitro and in vivo by concanavalin A stimulation.

Lefebvre DJ, Meerts P, Costers S, Misinzo G, Barbé F, Van Reeth K, Nauwynck HJ.

Vet Microbiol. 2008 Nov 25;132(1-2):74-86. doi: 10.1016/j.vetmic.2008.05.004. Epub 2008 May 9.

 

Antigenic differences among porcine circovirus type 2 strains, as demonstrated by the use of monoclonal antibodies.

Lefebvre DJ, Costers S, Van Doorsselaere J, Misinzo G, Delputte PL, Nauwynck HJ.

J Gen Virol. 2008 Jan;89(Pt 1):177-87.

 

Increased yield of porcine circovirus-2 by a combined treatment of PK-15 cells with interferon-gamma and inhibitors of endosomal-lysosomal system acidification.

Misinzo G, Delputte PL, Lefebvre DJ, Nauwynck HJ.

Arch Virol. 2008;153(2):337-42. Epub 2007 Dec 17.

 

 

 

Inhibition of endosome-lysosome system acidification enhances porcine circovirus 2 infection of porcine epithelial cells.

Misinzo G, Delputte PL, Nauwynck HJ.

J Virol. 2008 Feb;82(3):1128-35. Epub 2007 Nov 21.

 

Efficacy of an inactivated PRRSV vaccine: induction of virus-neutralizing antibodies and partial virological protection upon challenge.

Misinzo G, Delputte PL, Meerts P, Drexler C, Nauwynck HJ.

Adv Exp Med Biol. 2006;581:449-54. No abstract available.

 

Porcine circovirus 2 uses heparan sulfate and chondroitin sulfate B glycosaminoglycans as receptors for its attachment to host cells.

Misinzo G, Delputte PL, Meerts P, Lefebvre DJ, Nauwynck HJ.

J Virol. 2006 Apr;80(7):3487-94.

 

Correlation between the presence of neutralizing antibodies against porcine circovirus 2 (PCV2) and protection against replication of the virus and development of PCV2-associated disease.

Meerts P, Misinzo G, Lefebvre D, Nielsen J, Bøtner A, Kristensen CS, Nauwynck HJ.

BMC Vet Res. 2006 Jan 30;2:6.

 

Enhancement of porcine circovirus 2 replication in porcine cell lines by IFN-gamma before and after treatment and by IFN-alpha after treatment.

Meerts P, Misinzo G, Nauwynck HJ.

J Interferon Cytokine Res. 2005 Nov;25(11):684-93.

 

Binding and entry characteristics of porcine circovirus 2 in cells of the porcine monocytic line 3D4/31.

Misinzo G, Meerts P, Bublot M, Mast J, Weingartl HM, Nauwynck HJ.

J Gen Virol. 2005 Jul;86(Pt 7):2057-68.

 

Replication kinetics of different porcine circovirus 2 strains in PK-15 cells, fetal cardiomyocytes and macrophages.

Meerts P, Misinzo G, McNeilly F, Nauwynck HJ.

Arch Virol. 2005 Mar;150(3):427-41. Epub 2004 Dec 3.